Pioneering Immunity

Protecting Tomorrow

Next-generation vaccines that stop oral disease at its source

Our Mission

At Praetorian Bio, we’re building next-generation vaccines to tackle some of the world’s most overlooked yet widespread diseases — starting with cavities and gum disease. These conditions aren’t just inconvenient — they’re driven by aggressive pathogens, linked to serious systemic health risks, and represent a massive unmet medical need. By focusing our platform on validated microbial targets, we aim to deliver first-in-class prevention tools that are scalable, accessible, and game-changing — unlocking blockbuster potential while de-risking science and IP for future expansion.

Liam, Age 7, San Francisco

"He stopped smiling at school.”

Liam had four cavities by age seven—two of them deep enough to require general anesthesia. He missed school, feared dentists, and hid his smile. Cavities aren’t just a cosmetic issue—they’re the #1 chronic childhood disease. At Praetorian, we’re working on a vaccine to help kids like Liam stay healthy and confident for life.

Ana, 65, Amsterdam

“My dentist warned me about my heart.”

Ana thought bleeding gums were just part of aging—until her dentist explained the link between periodontal disease and heart disease. Science shows chronic gum inflammation can increase cardiovascular risk. We’re developing a preventive vaccine to disrupt this link before damage begins.

Rex, 5-Year-Old Vizsla

“Bad breath nearly cost him his teeth.”

Rex loved his walks—but hated visits to the vet. His owners were shocked to learn his gingivitis could lead to tooth loss and systemic illness. Dogs like Rex deserve better than painful dental cleanings under anesthesia. Praetorian is working on solutions that make canine care preventive—not reactive.

Clarck, Age 78, New York

“I brush. I floss. I still worry.”

Recent research links oral pathogens like P. gingivalis with Alzheimer’s disease. Eloise’s mother had dementia, and she’s committed to prevention. At Praetorian, we’re pioneering vaccines that don’t just protect smiles—they may help protect memories too.

Abhijit, Age 34, New Delhi

“I couldn’t afford to fix my teeth.”

Abhijit worked two jobs and skipped the dentist for years. By the time he saw a provider, he needed extractions and a bridge. Cavities and gum disease affect working adults disproportionately. We believe prevention should be accessible to everyone—regardless of income or insurance.

Nearly Half of the World Population Suffers from Oral Diseases

Despite being almost entirely preventable, oral diseases like cavities and periodontitis affect over 3.5B people globally — the most common chronic diseases worldwide. Beyond tooth loss and pain, these infections are increasingly linked to heart disease, Alzheimer’s, and premature birth. The burden is enormous — and preventable.

News & Insights

The latest updates from Praetorian Bio